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Vitamins Information (Home) > Side Effects > Alfalfa Alfalfa Side EffectsUse of the dried leaves of alfalfa in the amounts listed above is usually safe. There have been isolated reports of people who are allergic to alfalfa. Ingestion of very large amounts (the equivalent of several servings) of the seed and/or sprouts has been linked to the onset of systemic lupus erythematosus (SLE) in animal studies. It has also been linked to the reactivation of SLE in people consuming alfalfa tablets. SLE is an autoimmune illness characterized by inflamed joints and a high risk of damage to kidneys and other organs. The chemical responsible for this effect is believed to be canavanine. At the time of writing, there were no well-known drug interactions with alfalfa.
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