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Vitamins Information (Home) > Quick Information > Alpha Ketoglutarate (AKG) Alpha-ketoglutarate (AKG) is the nitrogen-free portion of the amino acids known as glutamine and glutamic acid. It is formed in the Krebs cycle, the energy-producing process that occurs in most body cells. AKG is used by cells during growth and in healing from injuries and other wounds, and is especially important in the healing of muscle tissue. A controlled study found that intravenous AKG prevented a decline in protein synthesis in the muscles of patients recovering from surgery. For these reasons, it has been speculated that oral AKG supplements might help improve strength or muscle-mass gains by weightlifters, but no research has been done to test this theory.
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