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Vitamins Information (Home) > Side Effects > Beta-Carotene Beta-Carotene Side EffectsBeta-carotene supplementation, even in very large amounts, is not known to cause any serious side effects, however, excessive intake (more than 100,000 IU, or 60 mg per day) sometimes gives the skin a yellow-orange hue. People taking beta-carotene for long periods of time should also supplement with vitamin E, as beta-carotene may reduce vitamin E levels. Beta carotene supplementation may also decrease blood levels of lutein, another carotenoid. Warning: Synthetic beta-carotene has now been linked to increased risk of lung cancer in smokers. Until more is known, smokers should avoid all beta-carotene supplements. Preliminary studies in animals indicate that beta-carotene supplementation, when combined with heavy alcohol consumption, may enhance liver toxicity. Until more is known, alcoholics and persons who consume alcohol on a daily basis should avoid supplementing with beta-carotene. One study showed a slightly increased risk of vascular surgery among people with intermittent claudication who took beta-carotene supplements. Until more is known, persons wishing to use beta-carotene supplements should first consult with their doctor. Certain medicines may interact with beta-carotene. Refer to drug interactions for a list of those medicines.
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