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Vitamins Information (Home) > Side Effects > Folic Acid Folic Acid Side EffectsFolic acid is not generally associated with side effects. However, folic acid supplementation can interfere with the laboratory diagnosis of vitamin B12 deficiency, possibly allowing the deficiency to progress undetected to the point of irreversible nerve damage. Although vitamin B12 deficiency is uncommon, no one should supplement with 1,000 mcg or more of folic acid without consulting a doctor. Vitamin B12 deficiencies often occur without anemia (even in people who do not take folic acid supplements). Some doctors do not know that the absence of anemia does not rule out a B12 deficiency. If this confusion delays diagnosis of a vitamin B12 deficiency, the patient could be injured, sometimes permanently. This problem is rare and should not happen with doctors knowledgeable in this area using correct testing procedures. Folic acid is needed by the body to utilize vitamin B12. Proteolytic enzymes inhibit folic acid absorption. People taking proteolytic enzymes are advised to supplement with folic acid. Certain medicines may interact with folic acid. Refer to drug interactions for a list of those medicines.
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