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Vitamins Information (Home) > Side Effects > Manganese


Manganese Side Effects

Amounts found in supplements (5–20 mg) have not been linked with any toxicity. Excessive intake of manganese rarely lead to psychiatric symptoms. However, most reports of manganese toxicity in otherwise healthy people have been in those people who chronically inhaled manganese dust at their jobs e.g., miners or alloy plant workers. Other sources of manganese intoxication are now recognized, including total parenteral nutrition (TPN) in patients who are being fed intravenously and pesticides containing manganese in agricultural workers who have been exposed. Preliminary research suggests that people with cirrhosis or cholestasis (blocked bile flow from the gall bladder) may not be able to properly excrete manganese. Until more is known, these people should not supplement manganese. Manganese supplementation (3–5 mg per day) has caused severe hypoglycemia (low blood sugar) in a person with insulin-dependent diabetes. People with diabetes who want to take manganese should consult their doctor. Several minerals, such as calcium and iron, and possibly zinc, reduce the absorption of manganese. Of these interactions, the link to iron may be the most important. In one study, women with high iron status had relatively poor absorption of manganese. In another report of manganese/iron interactions in women, increased intake of “non-heme iron” the kind of iron found in most supplements decreased manganese status. These interactions suggest that taking multi-minerals that include manganese may protect against manganese deficiencies that might otherwise be triggered by taking isolated mineral supplements, particularly iron. Certain medicines may interact with manganese. Refer to drug interactions for a list of those medicines.

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