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Vitamins Information (Home) > Deficiency Symptoms > SAMe
SAMe Deficiency SymptomsSAMe is normally produced in the liver from the amino acidmethionine which is abundant in most diets. Folic acid and vitamin B12 are necessary for the synthesis of SAMe, and deficiencies of these vitamins results in low concentrations of SAMe in the central nervous system. Low blood or central nervous system levels of SAMe have been detected in people with cirrhosis of the liver, coronary heart disease, Alzheimer’s disease, and depression.
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