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Vitamins Information (Home) > Side Effects > SAMe SAMe Side EffectsClinical trials in thousands of people for up to two years have demonstrated that SAMe is very well tolerated, much better than the medications with which it has often been compared. Occasional gastrointestinal upset may be experienced by some people. Researchers treating people with bipolar disorder (manic depression) have reported that SAMe could cause them to switch from depression to a manic episode. Certain medicines may interact with SAMe. Refer to drug interactions for a list of those medicines.
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