Selenium Side Effects

Selenium is safe at the level people typically supplement (100–200 mcg); however, taking more than 900 mcg of selenium per day has been reported to cause adverse effects in some people. Selenium toxicity can result in loss of fingernails, skin rash, and changes in the nervous system. In the presence of iodine-deficiency-induced goiter, selenium supplementation has been reported to exacerbate low thyroid function. Although most research suggests that selenium prevents cancer, one study found an increased risk of a type of skin cancer (squamous cell carcinoma) in people taking selenium supplements. The National Academy of Sciences recommends that selenium intake not exceed 400 mcg per day, unless the higher intake is monitored by a healthcare professional. Selenium enhances the antioxidant effect of vitamin E. Certain medicines may interact with selenium. Refer to drug interactions for a list of those medicines.

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