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Vitamins Information (Home) > Dosage > Vitamin B12 Vitamin B12 DosageMost people do not require vitamin B12 supplements. However, vegans should supplement with at least 2 to 3 mcg per day. People with pernicious anemia are often treated with injections of vitamin B12. However, oral administration of 1,000 mcg per day can be used reliably as an alternative to vitamin B12 injections. Absorption of vitamin B12 is reduced with increasing age. Some research suggests that elderly people may benefit from 10 to 25 mcg per day of vitamin B12. One study of elderly people with vitamin B12 deficiency suggested that as much as 500 to 1,000 mcg of vitamin B12 per day might be necessary to achieve optimal vitamin B12 status. Vitamin B12 status was measured in this study using a sensitive laboratory test (the plasma methylmalonic acid concentration). When vitamin B12 is used for therapeutic purposes other than correcting a deficiency, injections are usually necessary to achieve results. Sublingual forms of vitamin B12 are available, but there is no proof that they offer any advantage to oral supplements.
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